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The mutagenic potential of mefloquine was studied in a variety of assay systems includingAmes testa host-mediated assay in micefluctuation tests and a mouse micronucleus assaySeveral of these assays were performed with and without prior metabolic activationIn no instance was evidence obtained for the mutagenicity of mefloquine.

The potential case against the British Army appears to hinge on the extent to which it took sufficient measures to screen soldiers to check for such signs and symptoms.

This list is not complete and there may be other drugs that can interact with mefloquineTell your doctor about all your prescription and over-the-counter medicationsvitaminsmineralsherbal productsand drugs prescribed by other doctorsDo not start a new medication without telling your doctor.

The Patient Information LeafletPILis the leaflet included in the pack with a medicineIt is written for patients and gives information about taking or using a medicineIt is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged.

This appears to be the only clinically relevant interaction of this kind with Lariammefloquinealthough theoreticallycoadministration of other drugs known to alter cardiac conductioneganti-arrhythmic or beta-adrenergic blocking agentscalcium channel blockersantihistamines or H 1blocking agentstricyclic antidepressants and phenothiazinesmight also contribute to a prolongation of the QTc intervalThere are no data that conclusively establish whether the concomitant administration of mefloquine and the above listed agents has an effect on cardiac function.

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falciparum malaria in pediatric patients is supported by evidence from adequate and well-controlled studies of lariam mefloquine in adults with additional data from published open-label and comparative trials using lariam mefloquine to treat malaria caused by p.

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